The Aging Round Table - Circle of CUMC Postdocs

Thursday, October 25, 2018

The CAC Aging Round Table for CUMC postdoctoral scientists working on aging will take place on Thursday, October 25, 2018.  For more information about eligibility for the Aging Round Table, contact Caitlin Hawke, Senior Science and Strategy Officer of the Columbia Aging Center: cmh2197@cumc.columbia.edu.

Our speaker on October 25 will be Patrick Lao, PhD, Postdoctoral Research Scientist, Adam Brickman Laboratory. The abstract for his talk, "Tau PET imaging with MK6240 in Alzheimer's disease," is below.

 

ABSTRACT:

Hyperphosphorylated tau protein in neurofibrillary tangles and amyloid-beta protein in amyloid plaques are the pathological hallmarks of Alzheimer’s disease (AD). The goal of this work was to determine the spatial distribution of tau burden and its dependence on amyloid positivity at various stages of AD. Participants underwent amyloid PET (18F-Florbetaben), tau PET (18F-MK6240), and T1 MR imaging, as well as neuropsychological evaluation. Tau burden was compared across three groups (Amyloid Negative Control, Amyloid Positive Control, Amyloid Positive MCI/AD). Tau accumulation in the medial temporal cortex was evident in all groups, and spread to lateral temporal cortex with amyloid positivity, and spread further to frontal and parietal cortex with MCI or AD. In vivo patterns of tau accumulation from PET imaging with 18F-MK6240 closely resemble the pathohistological Braak staging of neurofibrillary tangles in AD. Ongoing work includes investigating the relationship between amyloid and tau burden with biomarkers of neurodegeneration.