Discover recent publications by the Columbia Aging Center faculty

Monday, August 8, 2022

Below is a list of recent publications by our Center's faculty. We invite you to discover their work. Articles are listed in reverse chronological order.


Rowe JW. Covid-19 and Aging : Challenges and Opportunities. Journals of Gerontology : Series A, volume 77, Issue 7, July 2022, pages 1349-1351.

Raffington RL, Belsky DW, Malanchini M, Tucker-Drob EM, Harden KP. Analysis of socioeconomic disadvantage and pace of aging measured in saliva DNA methylation of children and adolescents. Pediatrics. Preprint available on BioRxiv. In press.

Belsky DW, Caspi A, Corcoran DL, Sugden K, Poulton R, Arseneault L, Baccarelli A, Chamarti K, Gao X, Hannon E, Harrington HL, Houts R, Kothari M, Kwon D, Mill J, Schwartz J, Vokonas P, Wang C, Williams B, Moffitt TE. DunedinPACE: A DNA methylation biomarker of the Pace of Aging. eLife, 11:e73420, 2022.

Rowe JW and Berkman L. Decompression of Morbidity and the Workforce. Nature Aging. I2,3-4, January 20, 2022. (

Graf GH, Zhang Y, Domingue B, Harris KM, Kothari M, Kwon D, Muennig PA, Belsky DW. Social mobility and biological aging among older adults in the United States. PNAS Nexus, pgac029. Published online March 29, 2022.

Kalia V, Belsky DW, Baccarelli AA, Miller GW. An exposomic framework to uncover environmental drivers of aging. Exposome. Published online, March 4, 2022 (

Raffington LR, Belsky DW. Integrating DNA-methylation measures of biological aging into social determinants of health research. Current Environmental Health Reports (doi:10.1007/s40572-022-00338-8), Published online Feb 18, 2022. 

Stebbins RC, Yang CY, Reason M, Aiello AE, Belsky DW, Harris KM, Plassman BL. Occupational cognitive stimulation, socioeconomic status, and cognitive functioning in young adulthood. SSM Population Health, 17 (2022) 101024.

Walsh CE, Yang YC, Oi K, Aiello A, Belsky DW, Harris KM, Plassman B. Age Profiles of Cognitive Decline and Dementia in Late Life in the Aging, Demographics and Memory Study (ADAMS). Journals of Gerontology, Series B: Social Sciences. Published online, February 16, 2022. (



Zeki Al Hazzouri A, Vittinghoff E, Hoang T, Golden SH, Fitzpatrick AL, Zhang A, Grasset L, Yaffe K. Body Mass Index in Early Adulthood And Dementia in Late Life: Findings From A Pooled Cohort. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association. Accepted.

Wang C, Huertas DS, Carstensen L , Rowe JW, Finkelstein R, Jackson R. Rethinking the Urban Physical Environment for Century-Long Lives: From Age Friendly to Longevity Ready Cities. Nature Aging 1,1088-1095 (2021) (

Veenstra D,  Rowe JW, Pagan J, et al  Reimbursement for Genetic Variant Reinterpretation: Five Questions Payers Should Ask. Am Journal of Managed Care 2021:27.10

Rehkopf D, Furstenberg  FF, Elser H, Jackson C, Levy N,  Rowe JW and the Aging Society Network. A U.S. State Index of Successful Aging Differences Between States and Over Time. Milbank Quarterly, November 23, 2021. (

Becker J, Burik CAP, Goldman G, Wang N, Jayashankar H, Bennett M, Belsky DW, Karlsson Linner R, Ahlskog R, Kleinman A, Hinds DA, 23andMe Research Group, Caspi A, Corcoran DL, Moffitt TE, Poulton R, Sugden K, Williams BS, Harris KM, Steptoe A, Ajnakina O, Milani L, Esko T, Iacono WG, McGue M, Magnusson PKE, Mallard TT, Harden KP, Tucker-Drob EM, Herd P, Freese J, Young A, Beauchamp JP, Koellinger P, Oskarsson S, Johannesson M, Visscher PM, Meyer MN, Laibson D, Cesarini D, Benjamin DJ, Turley P, Okbay A. Resource Profile and User Guide of the Polygenic Index Repository. Nature Human Behaviour, 5:1744-58, 2021. PMC8678380

Yang YC, Walsh CE, Johnson M, Reason M, Aiello A, Belsky DW, Harris KM, Curran P Chanti-Ketterl M.  Life Course Trajectories of Body Mass Index from Adolescence to Old Age: Racial/Ethnic and Educational Disparities. Proceedings of the National Academy of Sciences USA, 118(17)e2020167118, 2021. PMC8092468

Crowe CL, Domingue BW, Graf GH, Keyes KM, Kwon D, Belsky DW. Associations of Loneliness and Social Isolation with Healthspan and Lifespan in the US Health and Retirement Study. Journals of Gerontology, Series A: Medical Sciences, 76(11):1997-2006. PMC8514074

Graf GH, Crowe CL, Kothari M, Kwon D, Manly JJ, Turney IC, Valeri L, Belsky DW. Testing Black-White disparities in biological aging in older adults in the United States: Analysis of DNA methylation and blood chemistry methods. American Journal of Epidemiology. Published online December 1, 2021.

Kwon D, Belsky DW. A toolkit for quantification of biological age from blood-chemistry and organ-function-test data: BioAge. Geroscience, 43:2795-2808.

Schrempft S, Belsky DW, Draganski B, Kliegel M, Vollenweider P, Marques-Vidal P, Preisig M, Stringhini S. Associations between life course socioeconomic conditions and the Pace of Aging. Journals of Gertonology Series A, Published online December 24, 2021.

Dorling JL, Belsky DW, Racette SB, Das SK, Ravussin E, Redman LM, Hochsmann C, Huffman KM, Kraus WE, Kobor M, McIsaac J, Lin D, Corcoran DL, Martin CK. Association between the FTO rs9939609 single nucleotide polymorphism and dietary adherence during a 2-year caloric restriction intervention: Exploratory analyses from CALERIETM phase 2. Experimental Gerontology, 2021, 155:111555. PMC8720865

Mian O, Anderson LN, Belsky DW, Gonzalez A, Ma J, Sloboda DM, Bowdish DME, Verschoor CP. Associations of Adverse Childhood Experiences with Frailty in Older Adults: A Cross-Sectional Analysis of Data from the Canadian Longitudinal Study on Aging. Gerontology, Published online Dec 1, 2021.

Wertz J, Israel S, Arseneault L, Belsky DW, Bourassa KJ, Harrington HL, Houts R, Poulton R, Richmond-Rakerd L, Roysamb E, Moffitt TE, Caspi A. Vital personality scores and healthy aging: Life-course associations and familial transmission. Social Science and Medicine, 285:114283, 2021. PMC8482063

Chanti-Ketterl M, Stebbins RC, Obhi HK, Belsky DW, Plassman BL, Yang CY. Sex differences in the association between metabolic dysregulation and cognitive aging: the Health and Retirement Study.  Journals of Gerontology Series A: Medical Sciences, Published online October 4, 2021.

Chen C, Maung. K, Rowe JW and the Aging Society Research Network . Gender Differences in Countries’ Adaptation to Societal Aging. Lancet Healthy Longevity V2 issue 8 E460-469. August 2021. (doi:

Da Silva Jr. JB, Rowe JW, Jauregui JR. Healthy aging in the Americas. Rev Panam Salud Publica. 2021;45:e116. (

Zeki Al Hazzouri A, Caunca MR, Jawadekar N, Grasset L, Elfassy T, Odden MC, Wu C, Elbejjani M, Launer L, Yaffe K. Associations between 20-year lipid variability throughout young adulthood and midlife cognitive function and brain integrity. J Gerontol A Biol Sci Med Sci. 2021 Apr 11:glab108.

Sherman J, Verstandig G, Rowe JW, and Brumer Y. Application of machine learning to large in-vitro databases to identify drug-cancer cell interactions. Oncogene. May 5, 2021 (

Rowe JW. The US Eldercare Workforce : Falling Further Behind. Nature Aging. 12 April 2021.

Yaffe K, Vittinghoff E, Hoang T, Matthews K, Golden SH, Zeki Al Hazzouri A. Cardiovascular Risk Factors Across the Life Course and Cognitive Decline: A Pooled Cohort Study. Neurology. 2021 Mar 17:10.1212/WNL.0000000000011747.

Kothari M, Belsky DW. Unite to predict: Integrating the analysis of molecular data from different sources may improve our understanding of the effects of biological aging. eLife, 10:e66223, 2021

Agnew-Blais J, Belsky DW, Caspi A, Danese A, Moffitt TE, Polanczyk G, Sugden K, Williams B, Wertz J, Lewis C, Arseneault L. Polygenic risk and the course of attention-deficit/hyperactivity disorder from childhood to young adulthood: Findings from a nationally-representative cohort. Journal of the American Academy of Child and Adolescent Psychiatry, Published online Jan 11, 2021.

Fried LP, Cohen AA, Xue QL, et al. The physical frailty syndrome as a transition from homeostatic symphony to cacophony. Nature Aging 1, 36–46 (2021).

Zeki Al Hazzouri A, Zhang L, Murchland AR, Grasset L, Torres JM, Jones RN, Wong R, Glymour MM. Quantifying lifecourse drivers of international migration: A cross-national analysis of Mexico and the US. Epidemiology. 2021 Jan. doi: 10.1097/EDE.0000000000001266.

Zhou A, Sabatello M, Eyal G, Lee SS, Rowe JW, Stiles DF, Swanson A, Appelbaum PS. Is precision medicine relevant in the age of COVID-19? Genet Med. 2021 Jan 13:1-2.

Katz S, Sivaramakrishnan K, Thane P. To Understand All Life as Fragile, Valuable, and Interdependent: A Roundtable on Old Age and History. Radical History Review 2021 (139): 13–36.

Demange P, Malanchini M, …. , Belsky DW, Harden KP, Nivard M. Investigating the Genetic Architecture of Non-Cognitive Skills Using GWAS-by-Subtraction. Nature Genetics, 53:35-44, 2021

Graf G, Biroli P, Belsky DW. Critical periods in child development and the transition to adulthood. JAMA Network Open, 4(1):e2033359, 2021



Sivaramakrishnan K. Contingent futures, Continuous Pasts: Experts, Activists, and Social and Disease transitions (1950–80s), in Epidemiological Change and Chronic Disease in Sub-Saharan Africa, eds. Megan Vaughan, Kafui Adjaye-Gbewonyo,and Marissa Mika (London: UCL Press, 2020 electronic, 2021 Hardcopy volume).

Sivaramakrishnan K. Endemic risks: influenza pandemics, public health, and making self-reliant Indian citizens. November 6, 2020. Journal of Global History.

Ghachem A, Fried LP, et al. Evidence from two cohorts for the frailty syndrome as an emergent state of parallel dysregulation in multiple physiological systems.  Biogerontology. 16 October 2020.

Fried LP. Designing a New Social Infrastructure to Combat Loneliness in Aging Adults. Generations 44(3). 

Pagán JA, Brown HS, Rowe JW, Schneider JE, Veenstra, DL, Gupta A, Berger SM, Chung WK, Appelbaum PS. Genetic Variant Reinterpretation: Economic and Population Health Management Challenges. Population Health Management. Sept 9 2020.

Prohaska T, Burholt V, Burns A, Golden J, Hawkley L, Lawlor B, Leavey G, Lubben J, O’Sullivan R, Perissinotto C, van Tilburg T, Tully M, Victor C, Fried LP. Consensus statement: loneliness in older adults, the 21st century social determinant of health? BMJ Open 2020;10:e034967. (doi: 10.1136/bmjopen-2019-034967).

Calvo E, Medina JT, Ornstein KA, Staudinger UM, Fried LP, Keyes KM. Cross-country and historical variation in alcohol consumption among older men and women: Leveraging recently harmonized survey data in 21 countries. Drug Alcohol Depend. 2020 Oct 1;215:108219. doi: 10.1016/j.drugalcdep.2020.108219. Epub 2020 Aug 4. PMID: 32795884.

Fried LP, Rowe JW. A Half-Century of Progress in Health: The National Academy of Medicine at 50: Health in Aging – Past, Present, and Future. 2020 Sept 30. New England Journal of Medicine. doi: 10.1056/NEJMp2016814

Newbury JB, Arseneault L, Caspi A, Moffitt TE, Odgers CL, Belsky DW, Sugden K, Williams B, Ambler AP, Matthews T, Fisher HL. Association between genetic and socioenvironmental risk for schizophrenia during upbringing in a UK longitudinal cohort. Psychological Medicine, doi: 10.1017/S0033291720003347. Published online September 25, 2020.

Shiau S, Bender AA, O'Halloran JA, Sundermann E, Aggarwal J, Althoff KN, Baker JV, Deeks S, Fried LP, Karpiak S, Karris MY, Marcotte TD, Nachega JB, Margolick JB, Erlandson KM, Moore DJ. The Current State of HIV and Aging: Findings Presented at the 10th International Workshop on HIV and Aging. AIDS Res Hum Retroviruses. 2020 Sep 23. doi: 10.1089/AID.2020.0128. Epub ahead of print. PMID: 32847368.

Fulmer TT, Koller CF, Rowe JW. Reimagining Nursing Homes in the Wake of COVID-19. NAM Perspectives, 2020 Sept 21.

Cohen AA, Levasseur M, Raina P, Fried LP, Fülöp T. Is Aging Biology Ageist? J Gerontol A Biol Sci Med Sci. 2020 Sep 16;75(9):1653-1655. doi: 10.1093/gerona/glz190. PMID: 31570936.

Swift SL, Elfassy T, Bailey Z, Florez H, Feaster DJ, Calonico S, Sidney S, Kiefe CI, Zeki Al Hazzouri A. Association of negative financial shocks during the Great Recession with depressive symptoms and substance use in the USA: the CARDIA study. J Epidemiol Community Health. 2020 Aug 11:jech-2020-213917. doi: 10.1136/jech-2020-213917. Epub ahead of print. PMID: 32788306.

Verschoor CP, Belsky DW, Ma J, Cohen AA, Raina P.  Comparing biological age estimates using domain-specific measures from the Canadian Longitudinal Study on Aging. Journals of Gerontology Series A: Biological Sciences, glaa151, Published online June 29, 2020.,

Le NP, Varadhan R, Fried LP, Cappola AR. Cortisol and Dehydroepiandrosterone Response to ACTH and Frailty in Older Women. J Gerontol A Biol Sci Med Sci. 2020 Jun 5:glaa134. doi: 10.1093/gerona/glaa134. Epub ahead of print. PMID: 32502234.

Elfassy T, Zeki Al Hazzouri A, Cai J, et al. Incidence of Hypertension Among US Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos, 2008 to 2017 [published online ahead of print, 2020 Jun 1]. J Am Heart Assoc. 2020;e015031. doi:10.1161/JAHA.119.015031

Grasset L, Smit RAJ, Caunca MR, ...Zeki Al Hazzouri A, et al. Association of High-Density Lipoprotein Cholesterol With Cognitive Function: Findings From the PROspective Study of Pravastatin in the Elderly at Risk [published online ahead of print, 2020 May 27]. J Aging Health. 2020;898264320916959. doi:10.1177/0898264320916959

Snyder-Mackler N, Burger JR, Gaydosh L, ... Belsky DW, et al. Social determinants of health and survival in humans and other animals. Science. 2020;368(6493):eaax9553. doi:10.1126/science.aax9553

Belsky DW, Caspi A, Arseneault L, et al. Quantification of the pace of biological aging in humans through a blood test, The DunedinPoAm DNA methylation algorithm [published online ahead of print, 2020 May 5]. Elife. 2020;9:e54870. doi:10.7554/eLife.54870

Caunca MR, Odden MC, Glymour MM, ...Zeki Al Hazzouri A, et al. Association of Racial Residential Segregation Throughout Young Adulthood and Cognitive Performance in Middle-aged Participants in the CARDIA Study [published online ahead of print, 2020 May 4]. JAMA Neurol. 2020;e200860. doi:10.1001/jamaneurol.2020.0860

Sugden KS, Hannon EJ, Arseneault L, Belsky DW, Corcoran DL, Fisher HL, Houts RM, Kandaswamy R, Moffitt TE, Poulton R, Prinz J, Rasmussen L, Williams BS, Wong CCY, Mill J, Caspi A. Assessing the reproducibility and integrity of DNA methylation measurement. Patterns 1, 10014, 2020.  

Muennig P, McEwen B, Belsky DW, Noble KG, Riccio J, Manly J. Determining the Optimal Outcome Measures for Studying the Social Determinants of Health. Int J Environ Res Public Health. 2020;17(9):E3028. Published 2020 Apr 27. doi:10.3390/ijerph17093028

Grasset L, Glymour MM, Yaffe K, ...Zeki Al Hazzouri A, et al. Association of traumatic brain injury with dementia and memory decline in older adults in the United States [published online ahead of print, 2020 Apr 22]. Alzheimers Dement. 2020;10.1002/alz.12080. doi:10.1002/alz.12080

Elfassy T, Zhang L, Raij L, ...Zeki Al Hazzouri A, et al. Results of the CARDIA study suggest that higher dietary potassium may be kidney protective [published online ahead of print, 2020 Apr 21]. Kidney Int. 2020;S0085-2538(20)30402-6. doi:10.1016/j.kint.2020.02.037

Schaich CL, Malaver D, Chen H, ...Zeki Al Hazzouri A. et al. Association of Heart Rate Variability With Cognitive Performance: The Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc. 2020;9(7):e013827. doi:10.1161/JAHA.119.013827

Domingue BW, Duncan L, Harrati A, Belsky DW. Short-term mental health sequelae of bereavement predict long-term physical health decline in older adults: US Health and Retirement Study Analysis [published online ahead of print, 2020 Apr 3]. J Gerontol B Psychol Sci Soc Sci. 2020;gbaa044. doi:10.1093/geronb/gbaa044

Richmond-Rakerd LS, Moffitt TE, Arseneault L, ...Belsky DW, et al. A polygenic score for age-at-first-birth predicts disinhibition [published online ahead of print, 2020 Mar 27]. J Child Psychol Psychiatry. 2020;10.1111/jcpp.13224. doi:10.1111/jcpp.13224

Harden KP, Domingue BW, Belsky DW, et al. Genetic associations with mathematics tracking and persistence in secondary school. NPJ Sci Learn. 2020;5:1. Published 2020 Feb 5. doi:10.1038/s41539-020-0060-2

Fried LP, Prohaska T, Burholt V, Burns A, Golden J, Hawkley L, Lawlor B, Leavey G, Lubben J. A unified approach to loneliness. Lancet 2020. 395:1365–75. doi: 10.1016/S0140-6736(19)32533-4.



Rehkopf DH, Furstenberg FF, Rowe JW. Trends in Mental and Physical Health-Related Quality of Life in Low-Income Older Persons in the United States, 2003 to 2017 [published correction appears in JAMA Netw Open. 2020 Jan 3;3(1):e1921166]. JAMA Netw Open. 2019;2(12):e1917868. Published 2019 Dec 2. doi:10.1001/jamanetworkopen.2019.17868

Dzau VJ, Inouye SK, Rowe JW, Finkelman E, Yamada T. Enabling Healthful Aging for All - The National Academy of Medicine Grand Challenge in Healthy Longevity. N Engl J Med. 2019;381(18):1699‐1701. doi:10.1056/NEJMp1912298

Hoogendijk EO, Afilalo J, Ensrud KE, Kowal P, Onder G, Fried LP. Frailty: implications for clinical practice and public health. Lancet. 2019;394(10206):1365‐1375. doi:10.1016/S0140-6736(19)31786-6

Cohen AA, Levasseur M, Raina P, Fried LP, Fülöp T. Is Aging Biology Ageist? [published online ahead of print, 2019 Oct 1]. J Gerontol A Biol Sci Med Sci. 2019;glz190. doi:10.1093/gerona/glz190

Eyal G, Sabatello M, Tabb K, ...Rowe JW...Sivaramakrishnan K, et al. The physician-patient relationship in the age of precision medicine. Genet Med. 2019;21(4):813‐815. doi:10.1038/s41436-018-0286-z