Discover recent publications by the Columbia Aging Center faculty

Thursday, September 30, 2021

Below is a list of recent publications by our Center's faculty. We invite you to discover their work. Articles are listed in reverse chronological order.


Zeki Al Hazzouri A, Vittinghoff E, Hoang T, Golden SH, Fitzpatrick AL, Zhang A, Grasset L, Yaffe K. Body Mass Index in Early Adulthood And Dementia in Late Life: Findings From A Pooled Cohort. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association. Accepted.

Veenstra D, Rowe JW, Pagan, J et al.  Reimbursement for Genetic Variant Reinterpretation : Five Questions Payers Should Ask. Am Journal of Managed Care. In press.

Rehkopf, D, Furstenberg  FF, Rowe JW and the Aging Society Network. Variations Between States and Over Time in Societal Adaptations to Aging: US Aging Society Index. Milbank Quarterly. In press

Becker J, Burik CAP, Goldman G, Wang N, Jayashankar H, Bennett M, Belsky DW, Karlsson Linner R, Ahlskog R, Kleinman A, Hinds DA, 23andMe Research Group, Caspi A, Corcoran DL, Moffitt TE, Poulton R, Sugden K, Williams BS, Harris KM, Steptoe A, Ajnakina O, Milani L, Esko T, Iacono WG, McGue M, Magnusson PKE, Mallard TT, Harden KP, Tucker-Drob EM, Herd P, Freese J, Young A, Beauchamp JP, Koellinger P, Oskarsson S, Johannesson M, Visscher PM, Meyer MN, Laibson D, Cesarini D, Benjamin DJ, Turley P, Okbay A. Resource Profile and User Guide of the Polygenic Index Repository. Nature Human. In press.

Yang YC, Walsh CE, Johnson M, Reason M, Aiello A, Belsky DW, Harris KM, Curran P Chanti-Ketterl M.  Life Course Trajectories of Body Mass Index from Adolescence to Old Age: Racial/Ethnic and Educational Disparities. Proceedings of the National Academy of Sciences USA. In press.

Raffington RL, Belsky DW, Malanchini M, Tucker-Drob EM, Harden KP. Analysis of socioeconomic disadvantage and pace of aging measured in saliva DNA methylation of children and adolescents. Pediatrics. Preprint available on BioRxiv. In press.

Zeki Al Hazzouri A, Caunca MR, Jawadekar N, Grasset L, Elfassy T, Odden MC, Wu C, Elbejjani M, Launer L, Yaffe K. Associations between 20-year lipid variability throughout young adulthood and midlife cognitive function and brain integrity. J Gerontol A Biol Sci Med Sci. 2021 Apr 11:glab108.

Rowe JW. The US Eldercare Workforce : Falling Further Behind. Nature Aging. 12 April 2021.

Yaffe K, Vittinghoff E, Hoang T, Matthews K, Golden SH, Zeki Al Hazzouri A. Cardiovascular Risk Factors Across the Life Course and Cognitive Decline: A Pooled Cohort Study. Neurology. 2021 Mar 17:10.1212/WNL.0000000000011747.

Kothari M, Belsky DW. Unite to predict: Integrating the analysis of molecular data from different sources may improve our understanding of the effects of biological aging. eLife, 10:e66223, 2021

Agnew-Blais J, Belsky DW, Caspi A, Danese A, Moffitt TE, Polanczyk G, Sugden K, Williams B, Wertz J, Lewis C, Arseneault L. Polygenic risk and the course of attention-deficit/hyperactivity disorder from childhood to young adulthood: Findings from a nationally-representative cohort. Journal of the American Academy of Child and Adolescent Psychiatry, Published online Jan 11, 2021.

Fried LP, Cohen AA, Xue QL, et al. The physical frailty syndrome as a transition from homeostatic symphony to cacophony. Nature Aging 1, 36–46 (2021).

Zeki Al Hazzouri A, Zhang L, Murchland AR, Grasset L, Torres JM, Jones RN, Wong R, Glymour MM. Quantifying lifecourse drivers of international migration: A cross-national analysis of Mexico and the US. Epidemiology. 2021 Jan. doi: 10.1097/EDE.0000000000001266.

Zhou A, Sabatello M, Eyal G, Lee SS, Rowe JW, Stiles DF, Swanson A, Appelbaum PS. Is precision medicine relevant in the age of COVID-19? Genet Med. 2021 Jan 13:1-2.

Katz S, Sivaramakrishnan K, Thane P. To Understand All Life as Fragile, Valuable, and Interdependent: A Roundtable on Old Age and History. Radical History Review 2021 (139): 13–36.

Demange P, Malanchini M, …. , Belsky DW, Harden KP, Nivard M. Investigating the Genetic Architecture of Non-Cognitive Skills Using GWAS-by-Subtraction. Nature Genetics, 53:35-44, 2021

Graf G, Biroli P, Belsky DW. Critical periods in child development and the transition to adulthood. JAMA Network Open, 4(1):e2033359, 2021


Sivaramakrishnan K. Contingent futures, Continuous Pasts: Experts, Activists, and Social and Disease transitions (1950–80s), in Epidemiological Change and Chronic Disease in Sub-Saharan Africa, eds. Megan Vaughan, Kafui Adjaye-Gbewonyo,and Marissa Mika (London: UCL Press, 2020 electronic, 2021 Hardcopy volume).

Sivaramakrishnan K. Endemic risks: influenza pandemics, public health, and making self-reliant Indian citizens. November 6, 2020. Journal of Global History.

Ghachem A, Fried LP, et al. Evidence from two cohorts for the frailty syndrome as an emergent state of parallel dysregulation in multiple physiological systems.  Biogerontology. 16 October 2020.

Fried LP. Designing a New Social Infrastructure to Combat Loneliness in Aging Adults. Generations 44(3). 

Pagán JA, Brown HS, Rowe JW, Schneider JE, Veenstra, DL, Gupta A, Berger SM, Chung WK, Appelbaum PS. Genetic Variant Reinterpretation: Economic and Population Health Management Challenges. Population Health Management. Sept 9 2020.

Prohaska T, Burholt V, Burns A, Golden J, Hawkley L, Lawlor B, Leavey G, Lubben J, O’Sullivan R, Perissinotto C, van Tilburg T, Tully M, Victor C, Fried LP. Consensus statement: loneliness in older adults, the 21st century social determinant of health? 2020 doi: 10.1136/bmjopen-2019-034967.

Calvo E, Medina JT, Ornstein KA, Staudinger UM, Fried LP, Keyes KM. Cross-country and historical variation in alcohol consumption among older men and women: Leveraging recently harmonized survey data in 21 countries. Drug Alcohol Depend. 2020 Oct 1;215:108219. doi: 10.1016/j.drugalcdep.2020.108219. Epub 2020 Aug 4. PMID: 32795884.

Fried LP, Rowe JW. A Half-Century of Progress in Health: The National Academy of Medicine at 50: Health in Aging – Past, Present, and Future. 2020 Sept 30. New England Journal of Medicine. doi: 10.1056/NEJMp2016814

Newbury JB, Arseneault L, Caspi A, Moffitt TE, Odgers CL, Belsky DW, Sugden K, Williams B, Ambler AP, Matthews T, Fisher HL. Association between genetic and socioenvironmental risk for schizophrenia during upbringing in a UK longitudinal cohort. Psychological Medicine, doi: 10.1017/S0033291720003347. Published online September 25, 2020.

Shiau S, Bender AA, O'Halloran JA, Sundermann E, Aggarwal J, Althoff KN, Baker JV, Deeks S, Fried LP, Karpiak S, Karris MY, Marcotte TD, Nachega JB, Margolick JB, Erlandson KM, Moore DJ. The Current State of HIV and Aging: Findings Presented at the 10th International Workshop on HIV and Aging. AIDS Res Hum Retroviruses. 2020 Sep 23. doi: 10.1089/AID.2020.0128. Epub ahead of print. PMID: 32847368.

Fulmer TT, Koller CF, Rowe JW. Reimagining Nursing Homes in the Wake of COVID-19. NAM Perspectives, 2020 Sept 21.

Cohen AA, Levasseur M, Raina P, Fried LP, Fülöp T. Is Aging Biology Ageist? J Gerontol A Biol Sci Med Sci. 2020 Sep 16;75(9):1653-1655. doi: 10.1093/gerona/glz190. PMID: 31570936.

Swift SL, Elfassy T, Bailey Z, Florez H, Feaster DJ, Calonico S, Sidney S, Kiefe CI, Zeki Al Hazzouri A. Association of negative financial shocks during the Great Recession with depressive symptoms and substance use in the USA: the CARDIA study. J Epidemiol Community Health. 2020 Aug 11:jech-2020-213917. doi: 10.1136/jech-2020-213917. Epub ahead of print. PMID: 32788306.

Verschoor CP, Belsky DW, Ma J, Cohen AA, Raina P.  Comparing biological age estimates using domain-specific measures from the Canadian Longitudinal Study on Aging. Journals of Gerontology Series A: Biological Sciences, glaa151, Published online June 29, 2020.,

Le NP, Varadhan R, Fried LP, Cappola AR. Cortisol and Dehydroepiandrosterone Response to ACTH and Frailty in Older Women. J Gerontol A Biol Sci Med Sci. 2020 Jun 5:glaa134. doi: 10.1093/gerona/glaa134. Epub ahead of print. PMID: 32502234.

Elfassy T, Zeki Al Hazzouri A, Cai J, et al. Incidence of Hypertension Among US Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos, 2008 to 2017 [published online ahead of print, 2020 Jun 1]. J Am Heart Assoc. 2020;e015031. doi:10.1161/JAHA.119.015031

Grasset L, Smit RAJ, Caunca MR, ...Zeki Al Hazzouri A, et al. Association of High-Density Lipoprotein Cholesterol With Cognitive Function: Findings From the PROspective Study of Pravastatin in the Elderly at Risk [published online ahead of print, 2020 May 27]. J Aging Health. 2020;898264320916959. doi:10.1177/0898264320916959

Snyder-Mackler N, Burger JR, Gaydosh L, ... Belsky DW, et al. Social determinants of health and survival in humans and other animals. Science. 2020;368(6493):eaax9553. doi:10.1126/science.aax9553

Belsky DW, Caspi A, Arseneault L, et al. Quantification of the pace of biological aging in humans through a blood test, The DunedinPoAm DNA methylation algorithm [published online ahead of print, 2020 May 5]. Elife. 2020;9:e54870. doi:10.7554/eLife.54870

Caunca MR, Odden MC, Glymour MM, ...Zeki Al Hazzouri A, et al. Association of Racial Residential Segregation Throughout Young Adulthood and Cognitive Performance in Middle-aged Participants in the CARDIA Study [published online ahead of print, 2020 May 4]. JAMA Neurol. 2020;e200860. doi:10.1001/jamaneurol.2020.0860

Sugden KS, Hannon EJ, Arseneault L, Belsky DW, Corcoran DL, Fisher HL, Houts RM, Kandaswamy R, Moffitt TE, Poulton R, Prinz J, Rasmussen L, Williams BS, Wong CCY, Mill J, Caspi A. Assessing the reproducibility and integrity of DNA methylation measurement. Patterns 1, 10014, 2020.  

Muennig P, McEwen B, Belsky DW, Noble KG, Riccio J, Manly J. Determining the Optimal Outcome Measures for Studying the Social Determinants of Health. Int J Environ Res Public Health. 2020;17(9):E3028. Published 2020 Apr 27. doi:10.3390/ijerph17093028

Grasset L, Glymour MM, Yaffe K, ...Zeki Al Hazzouri A, et al. Association of traumatic brain injury with dementia and memory decline in older adults in the United States [published online ahead of print, 2020 Apr 22]. Alzheimers Dement. 2020;10.1002/alz.12080. doi:10.1002/alz.12080

Elfassy T, Zhang L, Raij L, ...Zeki Al Hazzouri A, et al. Results of the CARDIA study suggest that higher dietary potassium may be kidney protective [published online ahead of print, 2020 Apr 21]. Kidney Int. 2020;S0085-2538(20)30402-6. doi:10.1016/j.kint.2020.02.037

Schaich CL, Malaver D, Chen H, ...Zeki Al Hazzouri A. et al. Association of Heart Rate Variability With Cognitive Performance: The Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc. 2020;9(7):e013827. doi:10.1161/JAHA.119.013827

Domingue BW, Duncan L, Harrati A, Belsky DW. Short-term mental health sequelae of bereavement predict long-term physical health decline in older adults: US Health and Retirement Study Analysis [published online ahead of print, 2020 Apr 3]. J Gerontol B Psychol Sci Soc Sci. 2020;gbaa044. doi:10.1093/geronb/gbaa044

Richmond-Rakerd LS, Moffitt TE, Arseneault L, ...Belsky DW, et al. A polygenic score for age-at-first-birth predicts disinhibition [published online ahead of print, 2020 Mar 27]. J Child Psychol Psychiatry. 2020;10.1111/jcpp.13224. doi:10.1111/jcpp.13224

Harden KP, Domingue BW, Belsky DW, et al. Genetic associations with mathematics tracking and persistence in secondary school. NPJ Sci Learn. 2020;5:1. Published 2020 Feb 5. doi:10.1038/s41539-020-0060-2

Fried LP, Prohaska T, Burholt V, Burns A, Golden J, Hawkley L, Lawlor B, Leavey G, Lubben J. A unified approach to loneliness. Lancet 2020. 395:1365–75. doi: 10.1016/S0140-6736(19)32533-4.



Rehkopf DH, Furstenberg FF, Rowe JW. Trends in Mental and Physical Health-Related Quality of Life in Low-Income Older Persons in the United States, 2003 to 2017 [published correction appears in JAMA Netw Open. 2020 Jan 3;3(1):e1921166]. JAMA Netw Open. 2019;2(12):e1917868. Published 2019 Dec 2. doi:10.1001/jamanetworkopen.2019.17868

Dzau VJ, Inouye SK, Rowe JW, Finkelman E, Yamada T. Enabling Healthful Aging for All - The National Academy of Medicine Grand Challenge in Healthy Longevity. N Engl J Med. 2019;381(18):1699‐1701. doi:10.1056/NEJMp1912298

Hoogendijk EO, Afilalo J, Ensrud KE, Kowal P, Onder G, Fried LP. Frailty: implications for clinical practice and public health. Lancet. 2019;394(10206):1365‐1375. doi:10.1016/S0140-6736(19)31786-6

Cohen AA, Levasseur M, Raina P, Fried LP, Fülöp T. Is Aging Biology Ageist? [published online ahead of print, 2019 Oct 1]. J Gerontol A Biol Sci Med Sci. 2019;glz190. doi:10.1093/gerona/glz190

Eyal G, Sabatello M, Tabb K, ...Rowe JW...Sivaramakrishnan K, et al. The physician-patient relationship in the age of precision medicine. Genet Med. 2019;21(4):813‐815. doi:10.1038/s41436-018-0286-z